Search
Abnova
PDPK1 Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
H00005170-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDPK1 (NP_112558.2, 1 a.a. approximately 429 a.a) full-length human protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAT RANSFVGTAQ YVSPELLTEK SACKSSDLWA LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNYD NLLSQFGCMQ VSSSSSSHSL SASDTGLPQR SGSNIEQYIH DLDSNSFELD LQFSEDEKRL LLEKQAGGNP WHQFVENNLI LKMGPVDKRK GLFARRRQLL LTEGPHLYYV DPVNKVLKGE IPWSQELRPE AKNFKTFFVH TPNRTYYLMD PSGNAHKWCR KIQEVWRQRY QSHPDAAVQ
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HGNC:8809; isoenzyme 1; kinase isoenzyme 1; lipoamide; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; Pkb kinase; PkB kinase like gene 1; PkB-like 1; predicted protein of HQ0461; unnamed protein product
Gene Aliases: PDK1; PRO0461
UniProt ID: (Human) O15530, (Mouse) Q9Z2A0
Entrez Gene ID: (Human) 5170, (Mouse) 18607
type B pancreatic cell development
hyperosmotic response
signal transduction
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
regulation of endothelial cell migration
negative regulation of cardiac muscle cell apoptotic process
cell migration
calcium-mediated signaling
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to insulin stimulus
negative regulation of toll-like receptor signaling pathway
intracellular signal transduction
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of mast cell degranulation
protein kinase B signaling
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
insulin-like growth factor receptor signaling pathway
focal adhesion assembly
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
cellular response to epidermal growth factor stimulus
extrinsic apoptotic signaling pathway
intracellular signaling cassette
positive regulation of protein localization to plasma membrane
positive regulation of sprouting angiogenesis
positive regulation of vascular endothelial cell proliferation
negative regulation of endothelial cell apoptotic process
protein phosphorylation
actin cytoskeleton organization
T cell costimulation
protein autophosphorylation
vascular endothelial cell response to laminar fluid shear stress
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support