Search
Invitrogen
PMP22 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-67643
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human PMP22.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD25; Charcot-Marie-Tooth neuropathy 1A (greatly reduced nerve conduction velocity, hereditary motor sensory neuropathy Ia); growth arrest specific protein (gas3); growth arrest-specific protein 3; growth-arrest-specific Gas-3 homolog; peripheral myelin; peripheral myelin protein 22 kDa; peripheral myelin protein, 22 kDa; PMP-22; PMP22; SAG; schwann cell membrane glycoprotein; SR13 myelin protein; unnamed protein product
Gene Aliases: CIDP; CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; PMP-22; Sp110; Tr; TRE002; trembler
UniProt ID: (Human) Q01453, (Mouse) P16646, (Rat) P25094
Entrez Gene ID: (Human) 5376, (Mouse) 18858, (Rat) 24660
lipid metabolic process
autophagy
apoptotic process
immune response
cell adhesion
nervous system development
peripheral nervous system development
mating
adult walking behavior
cholesterol metabolic process
negative regulation of cell proliferation
adult locomotory behavior
response to bacterium
regulation of gene expression
proteasomal protein catabolic process
regulation of Schwann cell proliferation
positive regulation of gene expression
negative regulation of gene expression
fibroblast migration
negative regulation of neuron projection development
Schwann cell differentiation
Schwann cell development
transmission of nerve impulse
neuronal action potential propagation
neuronal action potential
myelination in peripheral nervous system
lamellipodium assembly
actin cytoskeleton organization
cell differentiation
paranodal junction assembly
membrane raft organization
bleb assembly
myelin assembly
regulation of glial cell apoptotic process
cellular response to heat
cellular response to unfolded protein
response to endoplasmic reticulum stress
multicellular organism growth
Schwann cell migration
gliogenesis
myelination
proteasome-mediated ubiquitin-dependent protein catabolic process
neuronal ion channel clustering
peripheral nervous system neuron axonogenesis
regulation of inflammatory response
neuromuscular process
striated muscle cell differentiation
muscle cell development
vestibular reflex
axon development
motor behavior
aggresome assembly
basement membrane organization
neuromuscular junction development, skeletal muscle fiber
regulation of apoptotic signaling pathway
chemical synaptic transmission
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support