Invitrogen

PPARGC1A Polyclonal Antibody

6 Published Figures
15 References
View all (2) PPARGC1A antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support
PPARGC1A Polyclonal Antibody

Product Details

PA5-72948

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

1:1,000
View 2 publications 2 publications

Flow Cytometry (Flow)

1-2.5 µg/mL
-

Immunoprecipitation (IP)

Assay-Dependent
View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

Assay-dependent
-

Affinity Purification (AP)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Dog, Goat, Hamster, Human, Mouse, Sheep, Pig, Rodent, Rat

Published species

C. elegans, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein made to an internal portion of the human PGC-1 alpha protein (within residues 400-550).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718802

Product Specific Information

Expected from sequence similarity: Mouse.

In IHC-P, staining is very strong in the nucleus with some cytoplasmic staining. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Target Information

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator activated receptor gamma coactivator 1; peroxisome proliferator activated receptor gamma coactivator-1; peroxisome proliferator activated receptor gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; pgc-1 alpha; PGC-1-alpha; PGC-1a-like; PGC-1alpha; Pgc-1alphaa; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR-gamma coactivator; PPAR-gamma coactivator 1-alpha; PPARgamma coactivator 1alpha; PPARGC-1-alpha

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Gene Aliases: A830037N07Rik; ENSMUSG00000079510; Gm11133; I79_015506; LEM6; PGC-1; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; Pgco1; PPARGC-1; PPARGC1; PPARGC1A

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UniProt ID: (Pig) Q865B6, (Human) Q9UBK2, (Mouse) O70343, (Rat) Q9QYK2

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Entrez Gene ID: (Goat) 100861288, (Pig) 397013, (Sheep) 443270, (Dog) 479127, (Human) 10891, (Chinese hamster) 100753651, (Mouse) 19017, (Rat) 83516

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Function(s)
DNA binding transcription coactivator activity RNA binding ligand-dependent nuclear receptor binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding nucleotide binding RNA polymerase II transcription cofactor activity protein binding transcription factor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity peroxisome proliferator activated receptor binding alpha-tubulin binding androgen receptor binding promoter-specific chromatin binding nucleic acid binding chromatin binding transcription cofactor
Process(es)
response to dietary excess regulation of transcription, DNA-templated mitochondrion organization positive regulation of mitochondrion organization response to muscle activity respiratory electron transport chain circadian regulation of gene expression cellular response to oxidative stress regulation of circadian rhythm negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity adipose tissue development energy homeostasis positive regulation of cold-induced thermogenesis negative regulation of neuron death positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of ATP biosynthetic process response to reactive oxygen species mitophagy temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to ischemia galactose metabolic process gluconeogenesis transcription initiation from RNA polymerase II promoter mRNA processing protein complex assembly positive regulation of transcription from RNA polymerase II promoter by pheromones aging digestion circadian rhythm androgen metabolic process RNA splicing response to cold skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration fatty acid oxidation cerebellum development androgen receptor signaling pathway forebrain development positive regulation of histone acetylation cellular response to potassium ion response to statin response to drug response to starvation response to leucine cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization flavone metabolic process cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission cellular response to thyroid hormone stimulus response to metformin positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of energy homeostasis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of cellular metabolic process rhythmic process response to hypoxia response to organic cyclic compound response to activity response to nutrient levels cellular response to fatty acid
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