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Invitrogen
PRDX2 Polyclonal Antibody
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Product Details
PA5-18533
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (NVDDSKEYFSKHN) corresponding to the C-terminus amino acids of PRDX2 (aa 186-198).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; PRDX2; PRP; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; TSA; unnamed protein product
Gene Aliases: HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
UniProt ID: (Human) P32119
Entrez Gene ID: (Human) 7001
defense response to tumor cell
respiratory burst involved in inflammatory response
response to oxidative stress
regulation of hydrogen peroxide metabolic process
removal of superoxide radicals
positive regulation of blood coagulation
negative regulation of lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
cellular response to oxidative stress
T cell proliferation
hydrogen peroxide metabolic process
hydrogen peroxide catabolic process
regulation of apoptotic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of MAPK cascade
leukocyte activation
cell redox homeostasis
negative regulation of T cell differentiation
thymus development
extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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