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Invitrogen
PRRX1 Polyclonal Antibody
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PRRX1 Antibody (PA5-106700) in IHC (P)
Immunohistochemistry analysis of PRRX1 in mouse kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PRRX1 polyclonal antibody (Product # PA5-106700) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106700
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRRX1(Accession P54821), corresponding to amino acid residues A53-S103.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PRRX1.
靶标信息
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; MHox; Muscle homeobox protein; paired mesoderm homeobox 1; Paired mesoderm homeobox protein 1; Paired-related homeobox protein 1; PRX-1; rHox
基因别名: A230024N07Rik; AA755424; AI385634; AI843499; K-2; mHox; Pmx; PMX1; PRRX1; Prx-1; Prx1
UniProt ID: (Mouse) P63013, (Rat) P63014
Entrez Gene ID: (Mouse) 18933, (Rat) 266813
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
embryonic limb morphogenesis
inner ear morphogenesis
middle ear morphogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
neuron fate determination
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
cartilage development
palate development
regulation of neuron projection regeneration
neuronal stem cell population maintenance
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