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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Pan-cadherin Antibodies

          Invitrogen

          Pan-cadherin Polyclonal Antibody

          2个已发表图片
          17 篇参考文献
          查看其他11个Pan-cadherin抗体

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          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite Pan-cadherin Polyclonal Antibody

          • 抗体检测数据 (8)
          • 已发表图片 (2)
          Pan-cadherin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Pan-cadherin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 10

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          Pan-cadherin Antibody (71-7100) in ICC/IF

          Immunofluorescence analysis of Pan-Cadherin was performed using 90% confluent log phase Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Cadherin pan Rabbit Polyclonal Antibody (Product # 71-7100) at 2 µg/mL in 0.1% BSA and incubated for 3 hours... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          Pan-cadherin Antibody in Immunocytochemistry (ICC/IF)
          Pan-cadherin Antibody in Immunocytochemistry (ICC/IF)
          Pan-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Pan-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Antibody in Western Blot (WB)
          Pan-cadherin Polyclonal Antibody

          产品信息

          71-7100

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-2 µg/mL
          查看9篇已发表文章 9篇已发表文章

          免疫组化 (IHC)

          -
          查看2篇已发表文章 2篇已发表文章

          免疫组化(石蜡) (IHC (P))

          1:100
          查看1篇已发表文章 1篇已发表文章

          免疫细胞化学 (ICC/IF)

          2-3 µg/mL
          查看2篇已发表文章 2篇已发表文章

          酶联免疫吸附实验 (ELISA)

          Assay-dependent
          -

          亲和纯化 (AP)

          -
          查看1篇已发表文章 1篇已发表文章

          其他PubMed (Misc)

          -
          查看2篇已发表文章 2篇已发表文章
          产品规格

          种属反应

          Dog, Chicken, Human, Mouse, Non-human primate, Rat, Xenopus

          已发表种属

          Bovine, C. elegans, Dog, Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide derived from the carboxy-terminus of the chicken N-cadherin protein.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.25 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.4

          内含物

          0.1% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533992

          产品详细信息

          This peptide antibody is broadly cross-reactive with all members of the cadherin family of proteins including N-cadherin, E-cadherin, P-cadherin, and R-cadherin. The antibody also displays broad species cross-reactivity including human, bovine, mouse, rat, chicken, amphibian, as well as other species. Rabbit anti-pan-Cadherin is useful as both a ubiquitous cadherin probe as well as a marker for adherens junctions.

          71-7100 was used successfully in the immunofluorescence analysis of pan cadherin in MDCK cells.

          靶标信息

          Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDH1; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Epithelial cadherin; L-CAM; Liver cell adhesion molecule; liver cell adhesion protein; Maternally-expressed neural cadherin; N-cadherin; N-cadherin 1; Neural cadherin; neural calcium-dependent cell adhesion molecule; Neural-cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; unnamed protein product; Uvomorulin; XmN-cadherin; xTCAD-1

          查看更多 收起

          基因别名: AA960649; AI385538; Arc-1; AW120700; CAD4; Cadherin-1; cadherin-2; cadherin-4; Cadp; CD324; CD325; CDH1; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; K-CAM; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO; Uvomorulin; XELAEV_18024918mg; XELAEV_18046239mg

          查看更多 收起

          UniProt ID: (Chicken) P08641, (Dog) F1PAA9, (Human) P12830, (Chicken) Q90630, (Human) P19022, (Human) P22223, (Chicken) P24503, (Human) P55283, (Mouse) P09803, (Rat) Q9R0T4, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038, (Xenopus) P79883, (Xenopus) P30944

          查看更多 收起

          Entrez Gene ID: (Chicken) 415860, (Dog) 442858, (Human) 999, (Dog) 480169, (Chicken) 414745, (Human) 1000, (Dog) 611010, (Human) 1001, (Chicken) 414845, (Chicken) 419222, (Dog) 100685099, (Human) 1002, (Mouse) 12550, (Rat) 83502, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588, (Xenopus) 108702627, (Xenopus) 100337618

          查看更多 收起

          功能
          calcium ion binding protein binding cadherin binding beta-catenin binding ankyrin binding GTPase activating protein binding identical protein binding gamma-catenin binding glycoprotein binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion protein kinase binding protein phosphatase binding alpha-catenin binding extracellular matrix binding protein complex binding nitric-oxide synthase binding molecular_function protein domain specific binding metal ion binding enzyme binding cadherin
          参与通路
          homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly cell-cell adhesion via plasma-membrane adhesion molecules regulation of gene expression negative regulation of cell-cell adhesion negative regulation of cell migration adherens junction organization positive regulation of protein import into nucleus positive regulation of transcription, DNA-templated cellular response to lithium ion cellular response to indole-3-methanol protein localization to plasma membrane response to toxic substance single organismal cell-cell adhesion pituitary gland development extracellular matrix disassembly extracellular matrix organization neuron projection development response to drug positive regulation of transcription factor import into nucleus establishment of protein localization to plasma membrane cartilage condensation neural tube formation cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules brain development glial cell differentiation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration neural crest cell delamination positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation regulation of synaptic transmission, glutamatergic radial glial cell differentiation limb development neuroepithelial cell differentiation trigeminal ganglion formation trigeminal ganglion structural organization regulation of oligodendrocyte progenitor proliferation negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance cell-cell adhesion cell aggregation regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering cerebral cortex development regulation of myelination regulation of Rho protein signal transduction positive regulation of muscle cell differentiation protein heterooligomerization retina homeostasis visual perception positive regulation of gene expression positive regulation of keratinocyte proliferation hair cycle process keratinization positive regulation of monophenol monooxygenase activity negative regulation of transforming growth factor beta2 production wound healing positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen canonical Wnt signaling pathway regulation of hair cycle by canonical Wnt signaling pathway positive regulation of melanosome transport axon guidance positive regulation of axon extension in utero embryonic development trophectodermal cell differentiation epithelial cell morphogenesis sensory perception of sound protein metabolic process regulation of protein localization regulation of water loss via skin regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation protein homooligomerization intestinal epithelial cell development salivary gland cavitation regulation of branching involved in salivary gland morphogenesis bicellular tight junction assembly cellular response to amino acid stimulus cochlea development regulation of protein localization to cell surface regulation of neuron migration response to organic substance regulation of signal transduction
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