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Invitrogen
Pericentrin Recombinant Rabbit Monoclonal Antibody (PSH0-66)
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Pericentrin Antibody (MA5-51929) in ICC/IF
Immunofluorescence analysis of Pericentrin was performed using 70% confluent log phase HEK-293 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Pericentrin Rabbit Recombinant Monoclonal Antibody (PSH0-66) (Product # MA5-51929) at 1:300 dilution in 0.1%... View More
产品信息
MA5-51929
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH0-66
抗原
Recombinant protein within human aa 201-600/3,336.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence Similarities: 63% Mouse/No Cross with Rat.
Tissue Specificity: Expressed in all tissues tested, including placenta, liver, kidney and thymus.
Positive Control: HeLa cell lysate, HepG2 cell lysate, MCF7 cell lysate, K-562 cell lysate.
Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Predicted band size: 378 kDa.
靶标信息
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Kendrin; Pericentrin; pericentrin-2; pericentrin-380; Pericentrin-B
基因别名: KEN; KIAA0402; MOPD2; PCN; PCNT; PCNT2; PCNTB; PCTN2; SCKL4
UniProt ID: (Human) O95613
Entrez Gene ID: (Human) 5116
