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Invitrogen
Phospho-Aquaporin 2 (Ser269) Polyclonal Antibody
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Phospho-Aquaporin 2 (Ser269) Antibody (PA5-35388) in WB
Western blot of Aquaporin 2 in rat kidney lysate showing specific immunolabeling of a bands at ~29 kDa and 37 kDa corresponding to a glycosylated form of the Phospho-Aquaporin 2 (Ser269) polyclonal antibody (Product # PA5-35388) in the vasopressin (AVP) treated lane (+), but not in the control lane (-).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-35388
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser269 of rat AQP2 conjugated to KLH
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
规格
25 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 0.1mg/mL BSA
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine and mouse based on 100% sequence homology.
PA5-35388 is specific for the ~29kDa AQP2 protein phosphorylated at Ser269, and also recognizes the glycosylated form of AQP2 at ~37kDa. This antibody contains enough material to conduct 10 mini-Western blots.
靶标信息
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQP2; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; aquaporin-CD; Aquaporin2; Aquaporine 2; collecting duct water channel protein; kidney collecting duct principal cell apical membrane water channel; vasopressin-regulated; MGC34501; unnamed protein product; water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
基因别名: AQP-2; AQP-CD; aquaporin-2; cph; jpk; NDI2; WCH-CD
UniProt ID: (Human) P41181, (Rat) P34080, (Mouse) P56402
Entrez Gene ID: (Human) 359, (Rat) 25386, (Mouse) 11827
renal water homeostasis
water transport
actin filament organization
glycerol transport
protein homotetramerization
transmembrane transport
cellular response to copper ion
cellular response to mercury ion
metanephric collecting duct development
renal water transport
cell volume homeostasis
hyperosmotic response
female pregnancy
response to salt stress
response to hormone
actin filament depolymerization
response to lipopolysaccharide
response to glucagon
response to starvation
cellular response to water deprivation
response to calcium ion
positive regulation of calcium ion transport
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