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Invitrogen
Phospho-PDGFRA/PDGFRB (Tyr572, Tyr574) Polyclonal Antibody
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Phospho-PDGFRA/PDGFRB (Tyr572, Tyr574) Antibody (44-1000G) in ICC/IF
Immunofluorescence analysis of PDGFR alpha + beta (pYpY572/574) was done on 70% confluent log phase MCF7 cells treated with PDGF (50 ng/mL for 10 min). The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with PDGFR alpha + beta (pYpY572/574) Rabbit polyclonal Antibo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
44-1000G
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PDGFRA that contains tyrosines 572 and 574 and PDGFRB tyrosines 579 and 581. The sequence is conserved in PDGFRA mouse, rat and frog.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Activated tyrosine kinase PDGFRB; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); alpha-type platelet-derived growth factor receptor; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140 antigen-like family member B; CD140a antigen; MGC74795; PDGF alpha chain; PDGF beta chain; PDGF Receptor alpha; PDGF-R-alpha; PDGF-R-beta; pdgfr-a; PDGFR-alpha; PDGFR-beta; PGFRB; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor, beta polypeptide; unnamed protein product; V1-Pdgfrb
基因别名: CD140A; CD140B; IBGC4; IMF1; JTK12; KOGS; OPDKD; PDGFR; PDGFR-1; PDGFR-2; PDGFR1; PDGFR2; PENTT
UniProt ID: (Human) P16234, (Human) P09619, (Mouse) P26618, (Mouse) P05622
Entrez Gene ID: (Human) 5156, (Human) 5159, (Mouse) 18595, (Mouse) 18596
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
platelet-derived growth factor alpha-receptor activity
vascular endothelial growth factor-activated receptor activity
platelet-derived growth factor receptor binding
protein binding
ATP binding
vascular endothelial growth factor binding
protein homodimerization activity
macromolecular complex binding
platelet-derived growth factor binding
phospholipase C activator activity
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
GTPase activator activity
receptor binding
kinase activity
enzyme binding
protein kinase binding
phosphatidylinositol 3-kinase binding
luteinization
cell activation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
negative regulation of platelet activation
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
regulation of actin cytoskeleton organization
cellular response to reactive oxygen species
platelet-derived growth factor receptor-alpha signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
positive regulation of MAPK cascade
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
embryonic digestive tract morphogenesis
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
positive regulation of calcium-mediated signaling
positive regulation of chemotaxis
positive regulation of protein kinase B signaling
cardiac myofibril assembly
cell chemotaxis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
metanephric glomerular capillary formation
regulation of mesenchymal stem cell differentiation
angiogenesis
blood vessel development
in utero embryonic development
kidney development
tissue homeostasis
glycosaminoglycan biosynthetic process
signal transduction
positive regulation of smooth muscle cell migration
hemopoiesis
adrenal gland development
positive regulation of collagen biosynthetic process
positive regulation of Rho protein signal transduction
cell migration involved in vasculogenesis
intracellular signal transduction
metanephric mesenchymal cell migration
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
aorta morphogenesis
cellular response to platelet-derived growth factor stimulus
response to hydrogen peroxide
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of mitotic nuclear division
embryonic organ development
positive regulation of smooth muscle cell proliferation
skeletal system morphogenesis
smooth muscle tissue development
regulation of peptidyl-tyrosine phosphorylation
lung growth
cardiac vascular smooth muscle cell differentiation
cell migration involved in coronary angiogenesis
cellular response to hydrogen peroxide
smooth muscle cell chemotaxis
metanephric glomerular mesangium development
metanephric glomerular mesangial cell proliferation involved in metanephros development
positive regulation of calcium ion import
ruffle assembly
response to ceramide
positive regulation of intracellular signal transduction
positive regulation of reactive oxygen species metabolic process
positive regulation of hepatic stellate cell activation
positive regulation of DNA biosynthetic process
G-protein coupled receptor signaling pathway
smooth muscle adaptation
hematopoietic progenitor cell differentiation
response to stress
estrogen metabolic process
male gonad development
female gonad development
anatomical structure morphogenesis
organ morphogenesis
signal transduction involved in regulation of gene expression
extracellular matrix organization
lung development
male genitalia development
Leydig cell differentiation
odontogenesis of dentin-containing tooth
positive regulation of peptidyl-tyrosine phosphorylation
white fat cell differentiation
palate development
face morphogenesis
positive regulation of branching involved in lung morphogenesis
cellular response to amino acid stimulus
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