Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-TRPV1 (Ser502) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 9
Phospho-TRPV1 (Ser502) Antibody (PA5-106215) in IHC (P)
Immunohistochemistry analysis of Phospho-TRPV1 (Ser502) in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-TRPV1 (Ser502) polyclonal antibody (Product # PA5-106215) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-106215
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TRPV1(Accession Q8NER1), corresponding to amino acid residues around phosphorylated Ser502.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of VR1 only when phosphorylated at Ser502.
靶标信息
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Capsaicin receptor; cation channel; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor
基因别名: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1
UniProt ID: (Human) Q8NER1, (Rat) O35433, (Mouse) Q704Y3
Entrez Gene ID: (Human) 7442, (Rat) 83810, (Mouse) 193034
transmembrane signaling receptor activity
excitatory extracellular ligand-gated ion channel activity
calcium channel activity
calmodulin binding
ATP binding
calcium-release channel activity
phosphoprotein binding
ion channel activity
cation channel activity
protein binding
cation transmembrane transporter activity
ligand-gated ion channel activity
chloride channel regulator activity
identical protein binding
nucleotide binding
ion channel
transport
cell surface receptor signaling pathway
chemosensory behavior
thermoception
release of sequestered calcium ion into cytosol
calcium ion transmembrane transport
cellular response to alkaloid
cellular response to ATP
temperature homeostasis
fever generation
microglial cell activation
diet induced thermogenesis
peptide secretion
lipid metabolic process
calcium ion transport
inflammatory response
signal transduction
positive regulation of cytosolic calcium ion concentration
response to pH
response to heat
response to organonitrogen compound
glutamate secretion
urinary bladder smooth muscle contraction
sensory perception of pain
ion transmembrane transport
positive regulation of apoptotic process
response to peptide hormone
positive regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
sensory perception of mechanical stimulus
detection of chemical stimulus involved in sensory perception of pain
smooth muscle contraction involved in micturition
positive regulation of gastric acid secretion
cellular response to cytokine stimulus
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
cellular response to temperature stimulus
negative regulation of establishment of blood-brain barrier
cellular response to nerve growth factor stimulus
ion transport
cation transport
catagen
transmembrane transport
cation transmembrane transport
