Invitrogen

Pleiotrophin Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Pleiotrophin Polyclonal Antibody

产品信息

PA5-145349

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.01-2 µg/mL
-

免疫组化（石蜡） (IHC (P))

5-20 µg/mL
-
产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Bovine PTN protein, Gly33-Asp168 (Accession #P21782)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.05% Proclin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3094367

靶标信息

Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory peptide; heparin affin regulatory protein; heparin binding factor; heparin binding growth factor 8; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurite promoting factor; Heparin-binding neurite-promoting factor; heparin-binding neurotorphic factor; Heparin-binding neutrophic factor; neurite growth-promoting factor 1; OSF-1; Osteoblast-specific factor 1; osteoblastic cell factor; p18; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); PTN

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基因别名: HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF; OSF-1; Osf1; PTN

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UniProt ID: (Human) P21246, (Bovine) P21782, (Rat) P63090, (Mouse) P63089

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Entrez Gene ID: (Human) 5764, (Bovine) 280904, (Rat) 24924, (Mouse) 19242

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功能
protein phosphatase inhibitor activity growth factor activity heparin binding chondroitin sulfate proteoglycan binding chondroitin sulfate binding vascular endothelial growth factor binding heparan sulfate binding glycosaminoglycan binding growth factor
参与通路
liver development transmembrane receptor protein tyrosine phosphatase signaling pathway nervous system development heart development learning positive regulation of cell proliferation regulation of cell shape positive regulation of cell-substrate adhesion positive regulation of neuron projection development response to activity negative regulation of angiogenesis spinal cord development cerebellum development thalamus development bone mineralization lung development negative regulation of cell migration response to estradiol response to progesterone cellular response to UV cellular response to platelet-derived growth factor stimulus response to drug positive regulation of apoptotic process negative regulation of catalytic activity estrous cycle endothelial cell differentiation negative regulation of membrane potential negative regulation of epithelial cell proliferation positive regulation of cell division retinal rod cell differentiation negative regulation of glial cell proliferation long-term synaptic potentiation cellular response to vitamin D cellular response to hypoxia negative regulation of mesenchymal cell proliferation response to kainic acid rod bipolar cell differentiation response to ciliary neurotrophic factor positive regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of neuromuscular junction development response to nerve growth factor positive regulation of hepatocyte proliferation leukocyte chemotaxis involved in inflammatory response positive regulation of leukocyte chemotaxis integrin-mediated signaling pathway negative regulation of neuroblast proliferation memory regulation of endothelial cell migration response to auditory stimulus positive regulation of bone mineralization dendrite regeneration regulation of myelination negative regulation of phosphoprotein phosphatase activity tissue regeneration receptor clustering ossification involved in bone remodeling positive regulation of cell differentiation positive regulation of ossification decidualization regulation of synaptic plasticity oogenesis positive regulation of axon regeneration positive regulation of oligodendrocyte differentiation dendrite arborization positive regulation of dendrite development negative regulation of long-term synaptic potentiation regulation of hemopoiesis regulation of stem cell population maintenance positive regulation of stem cell differentiation ossification neuromuscular junction development skeletal muscle acetylcholine-gated channel clustering
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