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Prohibitin 2 Polyclonal Antibody

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Prohibitin 2 Polyclonal Antibody

产品信息

BS-10283R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human Prohibitin 2, amino acids 281-299.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B cell receptor associated protein 37; B-cell associated protein; B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; BAP-37; D-prohibitin; MGC117268; NB4 apoptosis/differentiation related protein; phb2; phb2 {ECO:0000250|UniProtKB:Q99623}; Prohibitin-2; Repressor of estrogen receptor activity; unnamed protein product

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基因别名: AU044498; BAP; Bap-37; Bap37; Bcap27; BCAP37; hBAP; p22; PHB2; PNAS-141; REA

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UniProt ID: (Human) Q99623, (Mouse) O35129, (Rat) Q5XIH7

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Entrez Gene ID: (Human) 11331, (Mouse) 12034, (Rat) 114766

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功能
protein binding estrogen receptor binding amide binding identical protein binding protein homodimerization activity sphingolipid binding protein heterodimerization activity chromatin binding protein C-terminus binding protein N-terminus binding molecular_function
参与通路
mitophagy positive regulation of immunoglobulin production protein import into nucleus mitochondrion organization sister chromatid cohesion cell migration regulation of complement activation intracellular estrogen receptor signaling pathway negative regulation of intracellular estrogen receptor signaling pathway mammary gland epithelial cell proliferation negative regulation of mammary gland epithelial cell proliferation RIG-I signaling pathway B cell activation negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity mammary gland branching involved in thelarche mammary gland alveolus development regulation of branching involved in mammary gland duct morphogenesis positive regulation of ERK1 and ERK2 cascade antiviral innate immune response regulation of cardiolipin metabolic process positive regulation of NIK/NF-kappaB signaling regulation of cytochrome-c oxidase activity protein import into nucleus, translocation transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of exit from mitosis positive regulation of cell cycle G1/S phase transition biological_process
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