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Invitrogen
Prolactin Receptor Polyclonal Antibody
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Prolactin Receptor Antibody (PA5149994) in ICC/IF
Immunocytochemistry analysis of Prolactin Receptor in Human MCF7 cells. Samples were incubated with Prolactin Receptor Polyclonal (Product # PA5149994) antibody using a dilution of 20 µg/mL, followed by FITC-Linked Caprine Anti-Rabbit IgG (2 µg/mL).
产品信息
PA5149994
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Prolactin Receptor (PRLR) (Gln25-Asp234)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytokine receptor; hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; prolactin receptor short isoform; secreted prolactin binding protein
基因别名: AI987712; HPRL; hPRLrI; MFAB; pPRLR-SF; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR
UniProt ID: (Pig) Q6JTA8, (Human) P16471, (Rat) P05710, (Mouse) Q08501
Entrez Gene ID: (Pig) 414916, (Human) 5618, (Rat) 24684, (Mouse) 19116
prolactin signaling pathway
oncostatin-M-mediated signaling pathway
leukemia inhibitory factor signaling pathway
steroid biosynthetic process
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
embryo implantation
lactation
regulation of cell adhesion
regulation of epithelial cell differentiation
T cell activation
activation of JAK2 kinase activity
negative regulation of apoptotic process
JAK-STAT cascade involved in growth hormone signaling pathway
mammary gland epithelial cell differentiation
prostate gland growth
mammary gland alveolus development
JAK-STAT cascade
cytokine-mediated signaling pathway
mammary gland epithelium development
