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Immunogen sequence: LMECEESPNGS EGACEKEKQS RDFQGRILSV DPEEEREEGP PRIPQADQWK SSNKSLVEAL GLEAEGAVPE
Highest antigen sequence identity to the following orthologs - mouse 52%, rat 49%.
RHOBTB1 (Rho-related BTB domain-containing protein 1) and RHOBTB3 (Rho-related BTB domain-containing protein 3) each contain two BTB (POZ) domains and belong to the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. While both RHOBTB1 and RHOBTB3 are expressed ubiquitously, RHOBTB1 is found at high levels in placenta, stomach, testis, kidney and skeletal muscle, whereas RHOBTB3 is found at high levels in neural and cardiac tissues. RHOBTB1 is thought to play a role in GTPase-mediated signaling and may participate in organization of the Actin filament system. Additionally, RHOBTB1 expression is decreased in head and neck carcinomas, suggesting a possible role for RHOBTB1 as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DBC2; KIAA0717; MGC33059; MGC33841; Rho-related BTB domain containing 1; Rho-related BTB domain-containing protein 1; RHOBTB2
基因别名: KIAA0740; RHOBTB1
UniProt ID: (Human) O94844
Entrez Gene ID: (Human) 9886
分子生物学功能: small GTPase