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Invitrogen
S100B Monoclonal Antibody (4C4.9)
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S100B Antibody (MA5-12969) in ICC/IF
Immunofluorescent analysis of S100 Protein (green) showing staining in the cytoplasm of C2C12 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a S100 Protein monoclonal antibody (Product # MA5-12969) in 3% BSA-PBS at a dilution of 1:50 and incubated overnight at 4°C in a humidified chamber. Cells were washed with PBST and incubated with a D... View More
产品信息
MA5-12969
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse
已发表种属
C. elegans,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4C4.9
抗原
Purified bovine brain S100 protein
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-12969 targets S100 Protein in IHC (P), ICC/IF and WB applications and shows reactivity with Bovine, Human, mouse, and Rat samples.
The MA5-12969 immunogen is purified bovine brain S100 protein.
靶标信息
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); S100 protein beta chain; S100 protein, beta polypeptide
基因别名: AI850290; Bpb; NEF; S100; S100-B; S100B; S100beta
UniProt ID: (Human) P04271, (Bovine) A4IFR6, (Mouse) P50114
Entrez Gene ID: (Human) 6285, (Bovine) 525716, (Mouse) 20203
axonogenesis
central nervous system development
learning or memory
memory
cell proliferation
positive regulation of cell proliferation
regulation of cell shape
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of neuronal synaptic plasticity
astrocyte differentiation
response to glucocorticoid
response to methylmercury
long-term synaptic potentiation
cellular response to hypoxia
negative regulation of skeletal muscle cell differentiation
regulation of translation
phosphorylation
negative regulation of kinase activity
positive regulation of complement activation
astrocyte activation
negative regulation of monocyte chemotactic protein-1 production
energy reserve metabolic process
cellular calcium ion homeostasis
regulation of cytokine biosynthetic process
regulation of long-term neuronal synaptic plasticity
positive regulation of synaptic transmission
