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Invitrogen
SDHB Monoclonal Antibody (CL0349)
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SDHB Antibody (MA5-31350) in ICC/IF
Immunofluorecent analysis of SDHB in A549 cells using SDHB Monoclonal Antibody (CL0349) (Product # MA5-31350). Staining shows specific staining in mitochondria in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
产品信息
MA5-31350
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL0349
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EGKQQYLQSI EEREKLDGLY ECILCACCST SCPSYWWNGD KYLGPAVLMQ AYRWMIDSRD DFTEERLAKL QDPFSLYRCH TIMNCTRTCP KGLNPGKAIA EIKKMMATY
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 97%.
靶标信息
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ92337; Ip; iron-sulfur subunit; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit; OTTHUMP00000044624; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
基因别名: CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHB; SDHIP
UniProt ID: (Human) P21912
Entrez Gene ID: (Human) 6390
