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Invitrogen
SH2D1A Polyclonal Antibody
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产品信息
PA5-102364
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SH2D1A(Accession O60880), corresponding to amino acid residues T53-E103.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SH2D1A.
靶标信息
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Duncan disease homolog; Duncan disease SH2-protein; Duncan's disease; FLJ18687; FLJ92177; HGNC:10820; RP5-1052M9.3; SH2 domain protein 1A; SH2 domain-containing protein 1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP
基因别名: DSHP; EBVS; Gm686; IMD5; LYP; MTCP1; RGD1562408; SAP; SAP/SH2D1A; SH2D1A; XLP; XLPD; XLPD1
UniProt ID: (Human) O60880, (Rat) B2RZ59, (Mouse) O88890
Entrez Gene ID: (Human) 4068, (Rat) 501502, (Mouse) 20400
