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Invitrogen
SHANK2 Polyclonal Antibody
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FIGURE: 1 / 1
SHANK2 Antibody (PA5-116834) in WB
Western blot analysis of SHANK2 in extracts of various cell lines. Samples were incubated with SHANK2 Polyclonal antibody (Product # PA5-116834) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 300s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-116834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SHANK2 (NP_0364412)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.36 mg/mL
Amount
236 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse liver, Rat liver
Immunogen sequence: PFALGANKDS LSAFEYPGPK RKLYSAVPGR LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD SQAETRADRS K
Target Information
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain-specific protein; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; PDZ-based scaffold protein; ProSAP1 protein; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; scaffolding protein; SH3 and multiple ankyrin repeat domains protein 2-like; SH3/ankyrin domain gene 2; Shank2; unnamed protein product
Gene Aliases: AUTS17; CORTBP1; CTTNBP1; mKIAA1022; ProSAP1; SHANK; Shank2E; SPANK-3
UniProt ID: (Human) Q9UPX8, (Mouse) Q80Z38, (Rat) Q9QX74
Entrez Gene ID: (Human) 22941, (Mouse) 210274, (Rat) 171093
synapse assembly
learning
memory
positive regulation of cell proliferation
associative learning
adult locomotory behavior
response to xenobiotic stimulus
adult behavior
social behavior
negative regulation of hippo signaling
exploration behavior
synapse organization
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
long term synaptic depression
vocalization behavior
regulation of postsynapse organization
maintenance of postsynaptic density structure
cognition
response to nutrient
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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