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Invitrogen
SIK2 Polyclonal Antibody
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SIK2 Antibody (PA5-97005) in WB
Western blot analysis of SIK2 in extracts of various cell lines. Samples were incubated with SIK2 Polyclonal antibody (Product # PA5-97005) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-97005
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 827-926 of human SIK2 (NP_0560061)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.93 mg/mL
规格
93 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PPPPPPRQPG AAPAPLQFSY QTCELPSAAS PAPDYPTPCQ YPVDGAQQSD LTGPDCPRSP GLQEAPSSYD PLALSELPGL FDCEMLDAVD PQHNGYVLVN; Positive Samples: U-87MG, SW620, A-549, HeLa, Jurkat, HepG2, Mouse fat, Mouse testis, Rat testis; Cellular Location: Cytoplasm
靶标信息
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: salt induceable kinase 2; Salt-inducible kinase 2; salt-inducible protein kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2
基因别名: G630080D20Rik; RGD1559698; Sik2; Snf1lk2
UniProt ID: (Mouse) Q8CFH6
Entrez Gene ID: (Mouse) 235344, (Rat) 315649
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