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Invitrogen
SIPA1 Polyclonal Antibody
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SIPA1 Antibody (PA5-88447) in WB
Western blot analysis of SIPA1 in extracts of various cell lines. Samples were incubated with SIPA1 Polyclonal antibody (Product # PA5-88447) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-88447
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 763-1042 of human SIPA1 (NP_69498529)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ESGRPRRSFS ELYTLSLQEP SRRGAPDPVQ DEVQGVTLLP TTKQLLHLCL QDGGSPPGPG DLAEERTEFL HSQNSLSPRS SLSDEAPVLP NTTPDLLLAT TAKPSVPSAD SETPLTQDRP GSPSGSEDKG NPAPELRASF LPRTLSLRNS ISRIMSEAGS GTLEDEWQAI SEIASTCNTI LESLSREGQP IPESGDPKGT PKSDAEPEPG NLSEKVSHLE SMLRKLQEDL QKEKADRAAL EEEVRSLRHN NRRLQAESES AATRLLLASK QLGSPTADLA; Positive Samples: Raji, K-562, HeLa, LO2, Mouse spleen; Cellular Location: Cytoplasm, Endomembrane system, Nucleus, Peripheral membrane protein, perinuclear region
靶标信息
The product of this gene is a mitogen induced GTPase activating protein. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1
基因别名: SIPA1; SPA1
UniProt ID: (Human) Q96FS4
Entrez Gene ID: (Human) 6494, (Mouse) 20469
cytoskeleton organization
negative regulation of cell adhesion
signal transduction
cell proliferation
negative regulation of cell growth
intracellular signal transduction
cellular response to water deprivation
positive regulation of GTPase activity
negative regulation of cell cycle
regulation of small GTPase mediated signal transduction
regulation of cell cycle
