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Invitrogen
SIPA1L1 Polyclonal Antibody
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产品信息
PA5-20847
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide from near the amino terminus of human SIPA1L1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is rat brain tissue lysate.
PA5-20847 can be used with blocking peptide PEP-0961.
靶标信息
Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E6-targeted protein 1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1 like 1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPA-1 like protein p1294; SPA-1-like protein p1294; SPAR; Spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP); WUGSC:H_DJ1140G11.1
基因别名: 4931426N11Rik; AW213287; E6TP1; KIAA0440; mKIAA0440; SIPA1L1; Spa-1; Spa1; SPAL; Spar
UniProt ID: (Human) O43166, (Rat) O35412, (Mouse) Q8C0T5
Entrez Gene ID: (Human) 26037, (Rat) 246212, (Mouse) 217692
biological_process
actin cytoskeleton reorganization
regulation of GTPase activity
ephrin receptor signaling pathway
regulation of synaptic plasticity
regulation of axonogenesis
regulation of small GTPase mediated signal transduction
regulation of dendritic spine morphogenesis
activation of GTPase activity
positive regulation of GTPase activity
regulation of dendrite morphogenesis
