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Invitrogen
SNAP alpha Polyclonal Antibody
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SNAP alpha Antibody (PA5-21782) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of SNAP alpha was performed in DIV10 rat E18 primary hippocampal neurons fixed in 4% paraformaldehyde at RT for 15 min. Green: SNAP alpha Polyclonal Antibody (Product # PA5 21782) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
产品信息
PA5-21782
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human alpha SNAP. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: HepG2, mouse brain, rat brain.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (89%), Pig (97%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha snap; alpha soluble NSF attachment protein; alpha-SNAP; Alpha-soluble NSF attachment protein; hydrocephaly with hop gait; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; SNAP-alpha
基因别名: 1500039N14Rik; a-SNAP; alpha-SNAP; AW209189; hyh; NAPA; RA81; Snap; SNAPA; SNARE
UniProt ID: (Human) P54920, (Rat) P54921, (Mouse) Q9DB05
Entrez Gene ID: (Human) 8775, (Rat) 140673, (Mouse) 108124
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
intra-Golgi vesicle-mediated transport
brain development
regulation of synaptic vesicle priming
neuron differentiation
synaptic transmission, glutamatergic
SNARE complex disassembly
apical protein localization
COPII vesicle coating
membrane fusion
transport
protein transport
vesicle-mediated transport
