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Invitrogen
SNRPE Polyclonal Antibody
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FIGURE: 1 / 3
SNRPE Antibody (PA5-98165) in ICC/IF
Immunofluorescent analysis of SNRPE in U251 cells using a SNRPE polyclonal antibody (Product # PA5-98165) at a dilution of 1:66. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-98165
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Small nuclear ribonucleoprotein E protein (1-92AA)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.6 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by SNRPE is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in SNRPE have been associated with hypotrichosis. Several pseudogenes of SNRPE have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B raf; B-raf; Braf; Sm protein E; Sm-E; Small nuclear ribonucleoprotein E; snRNP-E; snRNPE; unnamed protein product
Gene Aliases: HYPT11; Sm-E; SME; snRNP-E; SNRPE
Entrez Gene ID: (Human) 6635
spliceosomal tri-snRNP complex assembly
spliceosomal complex assembly
spliceosomal snRNP assembly
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
mRNA splicing, via spliceosome
7-methylguanosine cap hypermethylation
negative regulation of mRNA splicing, via spliceosome
nuclear histone mRNA catabolic process
U2-type prespliceosome assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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