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Invitrogen
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This target displays homology in the following species: Cow: 93%; Dog: 93%; Goat: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
This gene encodes a member of the sorting nexin family. Members of this family contain a phox domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hCG_23393; OTTHUMP00000035515; Sorting nexin-15
基因别名: Snx15
UniProt ID: (Rat) Q4V896
Entrez Gene ID: (Rat) 293691