Invitrogen

SNX6 Polyclonal Antibody

Name: SNX6 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-87586
Availability: InStock

查看其他7个SNX6抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

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SNX6 Antibody (PA5-87586) in WB

Western blot analysis of SNX6 in extracts of various cell lines. Samples were incubated with SNX6 Polyclonal antibody (Product # PA5-87586) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image SNX6 Polyclonal Antibody

产品信息

PA5-87586

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_0670723)

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.78 mg/mL

78 µg

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2804270

产品详细信息

Immunogen sequence: MTKEEFTKMK QELEAEYLAI FKKTVAMHEV FLCRVAAHPI LRRDLNFHVF LEYNQDLSVR GKNKKEKLED FFKNMVKSAD GVIVSGVKDV DDFFEHERTF LLEYHNRVKD ASAKSDRMTR SHKSAADDYN RIGSSLYALG TQDSTDICKF FLKVSELFDK TRKIEARVSA DEDLKLSDLL KYYLRESQAA KDLLYRRSRS LVDYENANKA LDKARAKNKD VLQAETSQQL CCQKFEKISE SAKQELIDFK TRRVAAFRKN LVELAELELK HAKGNLQLLQ NCLAVLNGDT; Positive Samples: HepG2, DU145, BT-474, Mouse kidney, Mouse lung, Mouse thymus, Mouse pancreas, Rat kidney; Cellular Location: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Early endosome membrane, Nucleus, Peripheral membrane protein

靶标信息

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。