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Invitrogen
SR-BI Polyclonal Antibody
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FIGURE: 1 / 11
SR-BI Antibody (PA1-16788) in ICC/IF
Immunocytochemistry analysis of SR-BI in HeLa cells. Samples were incubated with SR-BI polyclonal antibody (Product # PA1-16788) using a dilution of 2 µg/mL overnight at 4°C followed by anti-rabbit Dylight 488 (Green) at a dilution of 1:500. Cells were fixed and permeabilized for 10 minutes using -20°C MeOH. Alpha tubulin (DM1A) was used as a co-stain at a 1:1,000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.
Product Details
PA1-16788
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mustelid,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A C-terminal peptide containing residues from mouse SR-BI (within residues 450-509).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: antigen standard for SCARB1 (transient overexpression lysate).
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CD36-related class B scavenger receptor haSR-BI; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HaSR-BI; HDL QTL 1; High density lipoprotein receptor SR-BI; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SR-BII; SRB1
Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; haSR-bI; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI
UniProt ID: (Pig) Q8SQC1, (Human) Q8WTV0, (Rat) P97943, (Mouse) Q61009, (Chinese hamster) Q60417
Entrez Gene ID: (Rabbit) 100009590, (Pig) 397018, (Human) 949, (Rat) 25073, (Mouse) 20778, (Chinese hamster) 100736552
lipopolysaccharide binding
beta-amyloid binding
lipopolysaccharide receptor activity
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein A-I binding
high-density lipoprotein particle receptor activity
virus receptor activity
phosphatidylserine binding
transporter activity
protein binding
1-phosphatidylinositol binding
apolipoprotein binding
protein homodimerization activity
lipid transporter activity
membrane trafficking regulatory protein
endothelial cell proliferation
cholesterol catabolic process
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
transcytosis
intestinal absorption
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
androgen biosynthetic process
receptor-mediated endocytosis
positive regulation of endothelial cell migration
wound healing
lipoprotein metabolic process
viral entry into host cell
regulation of phagocytosis
steroid biosynthetic process
lipid transport
phagocytosis, recognition
cell adhesion
cholesterol transport
pattern recognition receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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