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Recommended positive controls: A549, HeLa.
Predicted reactivity: Mouse (95%), Rat (96%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory sperm binding protein Li 83p; Sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-linked
基因别名: DRS; ETX1; HEL-S-83p; SRPX; SRPX1
UniProt ID: (Human) P78539
Entrez Gene ID: (Human) 8406