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STK3 Monoclonal Antibody (4F7)

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STK3 Monoclonal Antibody (4F7)

产品信息

H00006788-M13A

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

酶联免疫吸附实验 (ELISA)

10 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

4F7

抗原

STK3 (AAH10640.1, 311 a.a. approximately 431 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

保存液

ascites

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM SKNVFPDNWK V

靶标信息

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: epididymis secretory sperm binding protein; hippo homolog; KB-1458E12.1; Mammalian STE20-like protein kinase 2; MST-2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase Krs-1; STE20-like kinase MST2; unnamed protein product

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基因别名: KRS1; MST2; STK3

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UniProt ID: (Human) Q13188

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Entrez Gene ID: (Human) 6788

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功能
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity identical protein binding protein serine/threonine kinase activator activity metal ion binding protein serine kinase activity transcription regulator activator activity
参与通路
neural tube formation endocardium development protein phosphorylation protein import into nucleus apoptotic process signal transduction JNK cascade central nervous system development cell proliferation negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression organ growth hippo signaling positive regulation of hippo signaling intracellular signal transduction positive regulation of apoptotic process regulation of MAPK cascade protein kinase B signaling positive regulation of fat cell differentiation positive regulation of JNK cascade negative regulation of organ growth epithelial cell proliferation negative regulation of epithelial cell proliferation protein stabilization protein tetramerization centrosome separation positive regulation of protein kinase B signaling canonical Wnt signaling pathway primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development protein localization to centrosome negative regulation of canonical Wnt signaling pathway hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
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