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SUMO1 Polyclonal Antibody
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Product Details
OSS00110G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse SUMO 1 conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Amount
500 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in human, rat and marmoset.
Specificity of this antibody: SUMO 1.
Target Information
SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CG4494-PA; GAP-modifying protein 1; GMP1; LD07775p; OTTHUMP00000202403; OTTHUMP00000202404; OTTHUMP00000202405; OTTHUMP00000202406; OTTHUMP00000202409; OTTHUMP00000202410; Sentrin; Sentrin-1; Small ubiquitin-related modifier 1; small ubiquitin-related modifier-1; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; Smt3C; SUMO-1; SUMO-1 related peptidase; Ubiquitin-homology domain protein PIC1; ubiquitin-like 1; ubiquitin-like 1 (sentrin); Ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1
Gene Aliases: GMP1; OK/SW-cl.43; PIC1; SENTRIN; SMT3; SMT3C; SMT3H3; SMTP3; SUMO-1; SUMO1; UBL1
UniProt ID: (Mouse) P63166, (Rat) Q5I0H3
Entrez Gene ID: (Mouse) 22218, (Rat) 301442
regulation of transcription, DNA-templated
protein sumoylation
PML body organization
positive regulation of protein complex assembly
regulation of protein stability
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of action potential
negative regulation of transcription, DNA-templated
palate development
regulation of cardiac muscle cell contraction
protein localization to nuclear pore
positive regulation of calcium-transporting ATPase activity
negative regulation of delayed rectifier potassium channel activity
regulation of calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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