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Invitrogen
Sudubrilimab Recombinant Human Monoclonal Antibody
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产品信息
MA5-59119
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Sudubrilimab, also known as HS636, is a humanized IgG1-k monoclonal antibody developed to target programmed death-ligand 1 (PD-L1, CD274). CD274 is a gene encoding a protein critical for immune checkpoint regulation. Located on chromosome 9, this protein is expressed on the surface of various cell types, including tumor cells, immune cells, and normal tissues. PD-L1 interacts with the PD-1 receptor on T cells to modulate immune responses, particularly by promoting self-tolerance and preventing autoimmunity. In the context of cancer, aberrant expression of CD274 allows tumor cells to evade immune surveillance, leading to immune escape. This mechanism has made CD274 a significant target for cancer immunotherapies, particularly immune checkpoint inhibitors such as pembrolizumab and nivolumab, which block the PD-1/PD-L1 interaction to restore anti-tumor immunity. Research on CD274 continues to reveal its role in various malignancies and its potential as a prognostic and therapeutic biomarker.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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