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Peptide sequence: ASVEPYCADI TSEEVRTLEE LLKPPEDEAE HYKIPPLGKH YSQRWAQEDL
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; FLJ20221; FLJ21329; hADA3; STAF54; Transcriptional adapter 3; Transcriptional adapter 3-like
基因别名: ADA3; hADA3; NGG1; STAF54; TADA3; TADA3L
UniProt ID: (Human) O75528
Entrez Gene ID: (Human) 10474
分子生物学功能: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme