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Invitrogen
TAOK1 Polyclonal Antibody
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FIGURE: 1 / 2
TAOK1 Antibody (PA5-101868) in ICC/IF
Immunocytochemistry analysis of TAOK1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with TAOK1 polyclonal antibody (Product # PA5-101868) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101868
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAOK1(Accession Q7L7X3), corresponding to amino acid residues R433-N483.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TAOK1.
Target Information
TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; tao; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1
Gene Aliases: 2810468K05Rik; AU020252; D130018F14Rik; KIAA1361; MAP3K16; MARKK; mKIAA1361; Psk2; Tao1; TAOK1
UniProt ID: (Mouse) Q5F2E8, (Rat) O88664
Entrez Gene ID: (Mouse) 216965, (Rat) 286993
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein kinase activator activity
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
DNA repair
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
regulation of apoptotic process
positive regulation of JNK cascade
regulation of cytoskeleton organization
execution phase of apoptosis
intracellular signal transduction
positive regulation of protein kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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