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Invitrogen
TIAM1 Polyclonal Antibody
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产品信息
PA5150132
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) (Asp1261-Lys1397)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: human T-lymphoma invasion and metastasis inducing TIAM1 protein; Rho guanine nucleotide exchange factor TIAM1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
基因别名: AI847750; D16Ium10; D16Ium10e; TIAM1
UniProt ID: (Human) Q13009
Entrez Gene ID: (Human) 7074, (Rat) 304109, (Mouse) 21844
receptor signaling protein activity
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
microtubule binding
lipid binding
kinase binding
Rac guanyl-nucleotide exchange factor activity
receptor tyrosine kinase binding
Rac GTPase binding
phospholipid binding
ephrin receptor binding
cell-matrix adhesion
small GTPase mediated signal transduction
positive regulation of neuron projection development
cell migration
Rac protein signal transduction
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of GTPase activity
ephrin receptor signaling pathway
positive regulation of axonogenesis
cardiac muscle hypertrophy
apoptotic process
positive regulation of protein binding
regulation of Rho protein signal transduction
response to cocaine
positive regulation of apoptotic process
positive regulation of JUN kinase activity
regulation of small GTPase mediated signal transduction
Wnt signaling pathway, planar cell polarity pathway
positive regulation of dendritic spine morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
protein localization to membrane
activation of GTPase activity
positive regulation of Schwann cell chemotaxis
regulation of dopaminergic neuron differentiation
neuron projection extension
regulation of non-canonical Wnt signaling pathway
signal transduction
intracellular signal transduction
regulation of GTPase activity
