Invitrogen

TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)

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TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)

产品信息

MA5-32787

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

-
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免疫细胞化学 (ICC/IF)

1:50-1:100
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流式细胞分析 (Flow)

1:50-1:100
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亲和纯化 (AP)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JM22-41

抗原

Recombinant protein within Human TLR2 aa 21-588
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2810063

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD282; TLR-2; Toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; Toll/interleukin-1 receptor-like protein 4

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基因别名: CD282; Ly105; TIL4; TLR2

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UniProt ID: (Human) O60603, (Mouse) Q9QUN7

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Entrez Gene ID: (Human) 7097, (Rat) 310553, (Mouse) 24088

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功能
lipopolysaccharide binding lipopolysaccharide receptor activity receptor activity transmembrane signaling receptor activity protein binding signaling pattern recognition receptor activity Toll-like receptor binding triacyl lipopeptide binding peptidoglycan binding protein heterodimerization activity diacyl lipopeptide binding lipoteichoic acid binding lipopeptide binding
参与通路
response to hypoxia microglial cell activation toll-like receptor signaling pathway response to molecule of fungal origin positive regulation of leukocyte migration cell surface pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway leukotriene metabolic process inflammatory response immune response I-kappaB phosphorylation negative regulation of cell proliferation response to bacterium response to toxic substance positive regulation of Wnt signaling pathway central nervous system myelin formation response to bacterial lipoprotein response to peptidoglycan response to lipopolysaccharide response to progesterone negative regulation of interleukin-12 production negative regulation of interleukin-17 production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production response to insulin positive regulation of toll-like receptor signaling pathway toll-like receptor 2 signaling pathway positive regulation of NF-kappaB import into nucleus detection of triacyl bacterial lipopeptide detection of diacyl bacterial lipopeptide positive regulation of tumor necrosis factor biosynthetic process chloramphenicol transport negative regulation of growth of symbiont in host innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter nitric oxide metabolic process positive regulation of oligodendrocyte differentiation positive regulation of cytokine secretion positive regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process induction by symbiont of defense-related host nitric oxide production positive regulation of macrophage cytokine production response to fatty acid cellular response to bacterial lipopeptide cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to diacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide response to molecule of bacterial origin cytokine secretion involved in immune response immune system process regulation of dendritic cell cytokine production signal transduction interleukin-10 production regulation of cytokine secretion apoptotic process positive regulation of gene expression lipopolysaccharide-mediated signaling pathway toll-like receptor TLR1:TLR2 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway
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