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Alomone Labs, LTD
TMEM16B (ANO2) (extracellular) Polyclonal Antibody
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TMEM16B (ANO2) (extracellular) Antibody (ACL-012-200UL) in IHC
Expression of Anoctamin-2 in mouse olfactory bulb - Immunohistochemical staining of mouse olfactory bulb using Anti-TMEM16B (ANO2) (extracellular) Antibody (#ACL-012), (1:200). A. Anoctamin-2 is detected in anoctamin-positive axons (arrows). B. Staining with mouse Anti-synaptophysin (red) and DAPI (blue) reveals the glomeruli of the olfactory bulb (asterisk). C. Merge of the above images reveals the spatial... View More
产品信息
ACL-012-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HSKRPEQWDLDHSLE, corresponding to amino acid residues 632-646 of mouse Anoctamin-2, 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCC's but has different biophysical characteristics such as voltage dependence and unitary conductance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ano2; anoctamin 2 isoform Adelta4; anoctamin 2 isoform Bdelta4; anoctamin 2-like; Anoctamin-2; Transmembrane protein 16B
基因别名: Ano2; BC033409; Tmem16b
UniProt ID: (Mouse) Q8CFW1
Entrez Gene ID: (Mouse) 243634, (Rat) 100361584
