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Invitrogen
TMEM24 Polyclonal Antibody
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产品信息
PA5-52780
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LEGTEELCCV AELDNPMQQK WTKPARAGSE VEWTEDLALD LGPQSRELTL KVLRSSSCGD TELLGQATLP VGSPSRPLSR RQLCPLTPGP GKALGPAATM AVELHYEEGS PRNLGTPTSS TPRPSITPTK KIELDRTIMP DGTIVTTV
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
靶标信息
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C2 domain-containing protein 2-like; C2CD2-like; Phospholipid transfer protein C2CD2L; Transmembrane protein 24
基因别名: C2CD2L; DLNB23; KIAA0285; TMEM24
UniProt ID: (Human) O14523
Entrez Gene ID: (Human) 9854
