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Alomone Labs, LTD
TMEM66 Polyclonal Antibody
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TMEM66 Antibody (ACC-067-200UL) in IHC (F)
Expression of TMEM66 in mouse cerebellum - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-TMEM66 Antibody (#ACC-067), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. TMEM66 immunoreactivity (green) appears in the molecular layer (MOL) and in neurons of the purkinje cell layer (P, arrows). B. Pre-incubation of the Antibody with TMEM66 Blocking Peptide (#BLP-CC0... View More
产品信息
ACC-067-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)ELGLSKLKESGKHQS, corresponding to amino acid residues 141-155 of rat SARAF, Intracellular, lumen.
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arrestin-E; HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; Protein FOAP-7; SARAF; SARAF long isoform; SARAF short isoform; SOCE-associated regulatory factor; Store-operated calcium entry-associated regulatory factor; testicular secretory protein Li 59; Transmembrane protein 66
基因别名: 1810045K07Rik; FOAP-7; HSPC035; NPD003; PSEC0019; SARAF; TMEM66; UNQ1967/PRO4499; XTP3
UniProt ID: (Human) Q96BY9, (Rat) Q6AYN2, (Mouse) Q8R3Q0
Entrez Gene ID: (Human) 51669, (Rat) 290796, (Mouse) 67887
