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Abnova
TMPRSS11B Polyclonal Antibody, MaxPab™
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产品信息
H00132724-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TMPRSS11B (NP_872308.1, 1 a.a. approximately 416 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GVVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE NDNVVVTGWG TLYMNGSFPV ILQEAFLKII DNKICNASYA YSGFVTDSML CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL
靶标信息
TMPRSS11B, a member of the transmembrane serine protease family, has recently gained attention for its role in promoting tumor growth, particularly in lung squamous cell carcinomas (LSCCs). This gene is located on chromosome 4q13.2 and encodes a protein involved in proteolytic processing of substrates, impacting cellular communication and tissue homeostasis. TMPRSS11B is upregulated in LSCCs, and its high expression correlates with poor survival rates in non-small cell lung cancer patients. Research has demonstrated that TMPRSS11B facilitates metabolic reprogramming in cancer cells, aiding their transformation and proliferation. In vitro studies with immortalized human bronchial epithelial cells have shown that TMPRSS11B enhances tumor growth, indicating its potential as a therapeutic target for lung cancer treatment. Moreover, TMPRSS11B depletion in immunocompetent mice led to reduced tumor burden and increased infiltration of immune cells, suggesting its influence on the tumor microenvironment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Airway trypsin-like protease 5; Transmembrane protease serine 11B
基因别名: HATL5; TMPRSS11B
UniProt ID: (Human) Q86T26
Entrez Gene ID: (Human) 132724
