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Suggested positive control: antigen standard for TNIP2 (transient overexpression lysate), mouse heart or lung tissue, mouse heart protein.
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN-2; Fetal liver LKB1-interacting protein; TNFAIP3-interacting protein 2; TNIP2
基因别名: 1810020H16Rik; ABIN-2; ABIN2; AI428870; FLIP1; KLIP; TNIP2
UniProt ID: (Human) Q8NFZ5, (Mouse) Q99JG7
Entrez Gene ID: (Human) 79155, (Mouse) 231130, (Rat) 305451