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Invitrogen
TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)
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TP63 Antibody (703809) in ICC/IF
Knockdown of TP63 was achieved by transfecting A431 cells with specific siRNA (Silencer® select Product # s13309, s13311). Immunofluorescence analysis was performed on A431 cells (untransfected, panel a-d), transfected with TP63 specific siRNA (panel i-l) or non-specific scrambled siRNA (panels e-h). Cells were fixed, permeabilized, and labeled with Anti-TP63 Recombinant Rabbit Monoclonal Antibody (Product # 703809, 1:100 dilution), followed by Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (... View More
产品信息
703809
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10H7L17
抗原
Protein corresponding to human TP63 [aa360-aa500]
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.
靶标信息
TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; deltaNp63delta; fifth splice variant; related to p53 and p73; first splice variant; related to p53 and p73; fourth splice variant; related to p53 and p73; Keratinocyte transcription factor KET; p40; p51; p53-like; p63; p63a; p73L; second splice variant; related to p53 and p73; sixth splice variant; related to p53 and p73; third splice variant; related to p53 and p73; TP63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like; unnamed protein product
基因别名: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L
UniProt ID: (Human) Q9H3D4
Entrez Gene ID: (Human) 8626
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
identical protein binding
sequence-specific DNA binding
metal ion binding
WW domain binding
MDM2/MDM4 family protein binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
establishment of planar polarity
morphogenesis of a polarized epithelium
hair follicle development
epithelial cell development
chromatin remodeling
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
Notch signaling pathway
spermatogenesis
pattern specification process
ectoderm and mesoderm interaction
positive regulation of cell proliferation
determination of adult lifespan
epidermis development
organ morphogenesis
epidermal cell differentiation
proximal/distal pattern formation
epidermal cell division
regulation of epidermal cell division
positive regulation of keratinocyte proliferation
keratinocyte differentiation
embryonic limb morphogenesis
prostate gland development
epithelial cell differentiation
polarized epithelial cell differentiation
hair follicle morphogenesis
negative regulation of intracellular estrogen receptor signaling pathway
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
post-anal tail morphogenesis
odontogenesis of dentin-containing tooth
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
skin morphogenesis
keratinocyte proliferation
positive regulation of cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
anatomical structure formation involved in morphogenesis
female genitalia morphogenesis
stem cell differentiation
protein tetramerization
neuron apoptotic process
cloacal septation
prostatic bud formation
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
establishment of skin barrier
stem cell proliferation
cellular senescence
skin epidermis development
positive regulation of cell cycle G1/S phase transition
positive regulation of somatic stem cell population maintenance
cranial skeletal system development
positive regulation of fibroblast apoptotic process
negative regulation of mesoderm development
positive regulation of stem cell proliferation
negative regulation of cellular senescence
positive regulation of apoptotic signaling pathway
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