Invitrogen

TRA2B Polyclonal Antibody

Name: TRA2B Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-30170

高级验证

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (6)
高级验证 (1)

TRA2B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRA2B Antibody (PA5-30170) in IHC (P)

SFRS10 Polyclonal Antibody detects TRA2B protein at nucleus on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. SFRS10 Polyclonal Antibody (Product # PA5-30170) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Product Image Gallery

TRA2B Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. HeLa cells were transfected with SFRS10 siRNA and decrease in signal was observed in Western Blot using SFRS10 Polyclonal Antibody (Product # PA5-30170). {KD}

产品信息

PA5-30170

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human TRA2B. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.41 mg/mL

41 µg

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2547644

产品详细信息

Recommended positive controls: JurKat.

Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (84%), Xenopus laevis (95%), Pig (100%), Chicken (99%), Sheep (99%), Rhesus Monkey (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

TRA2B (Transformer 2 Beta Homolog) is a serine/arginine-rich (SR-like) RNA-binding protein that functions as an important regulator of alternative pre-mRNA splicing. It binds to specific exonic splicing enhancer (ESE) sequences and promotes exon inclusion in a variety of target transcripts, thereby contributing to transcript diversity and post-transcriptional gene regulation. TRA2B plays roles in development, cell cycle regulation, and tissue-specific gene expression, and its dysregulation has been implicated in cancer and other diseases through altered splicing patterns. As part of the broader SR protein and splicing factor network, TRA2B interacts with additional components of the spliceosome to coordinate precise and context-dependent mRNA processing.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alternative splice variant of human splicing factor htra2-beta-1; protein phosphatase 1, regulatory subunit 156; RA301; serine/arginine-rich splicing factor 10; SIG-41; Silica-induced gene 41 protein; Splicing factor, arginine/serine-rich 10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); TRA-2 beta; TRA2-beta; Transformer-2 protein homolog B; Transformer-2 protein homolog beta; unnamed protein product

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基因别名: 5730405G21Rik; D16Ertd266e; Htra2-beta; PPP1R156; SFRS10; SIG-41; Silg41; SRFS10; Srsf10; TRA2-BETA; TRA2B; TRA2beta; TRAN2B

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UniProt ID: (Human) P62995, (Mouse) P62996, (Rat) P62997

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Entrez Gene ID: (Human) 6434, (Mouse) 20462, (Rat) 117259

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功能

nucleic acid binding RNA binding mRNA binding protein binding protein domain specific binding pre-mRNA binding identical protein binding nucleotide binding poly(A) RNA binding

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