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TRIM5 alpha Polyclonal Antibody
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FIGURE: 1 / 2
TRIM5 alpha Antibody (600-401-FP7) in IHC (P)
Immunohistochemistry of TRIM5 alpha antibody. Tissue: human uterus tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: TRIM5 alpha antibody at 2 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: TRIM5 alpha is cytoplasmic. Staining: TRIM5 alpha is stained with Toluidine blue.
Product Details
600-401-FP7
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-TRIM5 alpha antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the near the internal region of rhesus monkey TRIM5 alpha.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the tripartite motif family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coiled-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiquitinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:16276; OTTHUMP00000069812; RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5; TRIM (RBCC) family member; TRIM5 isoform iota; TRIM5 isoform kappa; trim5a; tripartite motif protein TRIM5; Tripartite motif-containing protein 5; tripartite motif-containing protein 5 alpha; unnamed protein product
Gene Aliases: RNF88; TRIM5; TRIM5alpha
UniProt ID: (Human) Q9C035
Entrez Gene ID: (Human) 85363
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
protein kinase binding
protein binding, bridging
pattern recognition receptor activity
identical protein binding
protein homodimerization activity
metal ion binding
ubiquitin protein ligase activity
activation of innate immune response
immune system process
autophagy
regulation of gene expression
protein ubiquitination
regulation of lipopolysaccharide-mediated signaling pathway
regulation of protein localization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
negative regulation by host of viral release from host cell
innate immune response
positive regulation of transcription, DNA-templated
regulation of viral entry into host cell
negative regulation of viral entry into host cell
positive regulation of NF-kappaB transcription factor activity
defense response to virus
protein K63-linked ubiquitination
regulation of primary metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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