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Invitrogen
TRIM71 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-21011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the carboxy terminus of human TRIM71.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-21011 can be used with blocking peptide PEP-1125.
Antibodies should not be exposed to prolonged high temperatures.
Target Information
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: abnormal cell LINeage LIN-41; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; homolog of C. elegans Lin-41; lin-41 homolog; protein lin-41 homolog; RBCC protein; RING-type E3 ubiquitin transferase TRIM71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing protein 71
Gene Aliases: 2610206G21Rik; Gm1127; HYC4; HYDCC1; LIN-41; LIN41; mlin-41; mLin41; RGD1566388
UniProt ID: (Human) Q2Q1W2, (Rat) D3ZVM4, (Mouse) Q1PSW8
Entrez Gene ID: (Human) 131405, (Rat) 301042, (Mouse) 636931
G1/S transition of mitotic cell cycle
protein polyubiquitination
fibroblast growth factor receptor signaling pathway
posttranscriptional regulation of gene expression
protein ubiquitination
negative regulation of translation
neural tube development
gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
3'-UTR-mediated mRNA destabilization
stem cell proliferation
regulation of neural precursor cell proliferation
neural tube closure
regulation of protein metabolic process
regulation of gene silencing by miRNA
positive regulation of gene silencing by miRNA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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