Search

  • Contact Us
  • Quick Order

Abnova

TYK2 Polyclonal Antibody, MaxPab™

View all (19) TYK2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

H00007297-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TYK2 (NP_003322.2, 1 a.a. approximately 1187 a.a) full-length human protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL LLFAQQICEG MAYLHSQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC

Target Information

Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2; unnamed protein product

View more View less

Gene Aliases: IMD35; JTK1; TYK2

View more View less

UniProt ID: (Human) P29597, (Mouse) Q9R117

View more View less

Entrez Gene ID: (Human) 7297, (Mouse) 54721

View more View less

Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups type 1 angiotensin receptor binding hormone receptor binding
Process(es)
regulation of transcription from RNA polymerase II promoter protein phosphorylation immune response JAK-STAT cascade cell proliferation cytokine-mediated signaling pathway regulation of cell-cell adhesion cell differentiation positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-23-mediated signaling pathway type III interferon-mediated signaling pathway positive regulation of T cell proliferation regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade regulation of alpha-beta T cell activation positive regulation of NK T cell proliferation interferon-gamma-mediated signaling pathway type I interferon signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway cellular response to virus interleukin-10-mediated signaling pathway positive regulation of protein localization to nucleus positive regulation of T-helper 17 type immune response transmembrane receptor protein tyrosine kinase signaling pathway phosphorylation cell migration peptidyl-tyrosine phosphorylation peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support