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Invitrogen
TYRO3 Polyclonal Antibody
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FIGURE: 1 / 1
TYRO3 Antibody (PA5-110535) in WB
Western blot analysis of TYRO3 in extracts of various cell lines. Samples were incubated with TYRO3 Polyclonal antibody (Product # PA5-110535) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110535
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human TYRO3 (NP_006284.2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.87 mg/mL
Amount
87 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PATNYSLRVR CANALGPSPY ADWVPFQTKG LAPASAPQNL HAIRTDSGLI LEWEEVIPEA PLEGPLGPYK LSWVQDNGTQ DELTVEGTRA NLTGWDPQKD LIVRVCVSNA VGCGPWSQPL VVSSHDRAGQ QGPPHSRTSW V
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase; FLJ16467; putative growth factor receptor kinase isoform B; putative growth factor receptor tyrosine kinase isoform A precursor; receptor tyrosine kinase; soluble tyro 3; soluble tyro3; styro 3; styro3; tyro 3; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase TIF; unnamed protein product
Gene Aliases: Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; tk19-1; TK19-2
UniProt ID: (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Mouse) 22174, (Rat) 25232
natural killer cell differentiation
protein phosphorylation
phagocytosis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
neuropeptide signaling pathway
gamete generation
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
negative regulation of neuron apoptotic process
negative regulation of innate immune response
viral entry into host cell
negative regulation of inflammatory response
negative regulation of lymphocyte activation
positive regulation of protein kinase B signaling
vagina development
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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