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Invitrogen
Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (R2F5)
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FIGURE: 1 / 10
Thymidylate Synthase Antibody (MA572221) in IHC (P)
Immunohistochemistry analysis of Thymidylate Synthase on paraffin-embedded Human Esophageal Cancer tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with Thymidylate Synthase Recombinant Monoclonal (Product # MA572221) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA572221
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R2F5
Immunogen
KLH conjugated synthetic peptide derived from human TYMS.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC88736; Thymidylate synthase; TS; TSase; tysy
Gene Aliases: OK/SW-cl.29; TS; TYMS
UniProt ID: (Mouse) P07607, (Rat) P45352
Entrez Gene ID: (Mouse) 22171, (Rat) 29261
dTMP biosynthetic process
nucleotide biosynthetic process
methylation
dUMP metabolic process
pyrimidine nucleobase metabolic process
dTTP biosynthetic process
aging
circadian rhythm
response to toxic substance
response to organic cyclic compound
immortalization of host cell by virus
uracil metabolic process
organ regeneration
response to progesterone
response to vitamin A
response to cytokine
response to drug
response to ethanol
tetrahydrofolate metabolic process
response to organophosphorus
developmental growth
cartilage development
response to glucocorticoid
response to folic acid
intestinal epithelial cell maturation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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