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Invitrogen
USP37 Polyclonal Antibody
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USP37 Antibody (PA5-75942) in WB
Western blot analysis of USP37 in Lane 1: the Brain tissue lysate of rat (30 µg), Lane 2: the Brain tissue lysate of mouse (30 µg), Lane 3: HeLa whole cell lysate (40 µg). Samples were incubated with USP37 polyclonal antibody (Product # PA5-75942) at a dilution of 1:500.
产品信息
PA5-75942
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 702-747 of Human USP37.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 37; tmp_locus_50; Ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; Ubiquitin thioesterase 37; ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37; usp37
基因别名: 4932415L06Rik; C330008N13Rik; KIAA1594; USP37
UniProt ID: (Human) Q53S10, (Mouse) Q8C0R0
Entrez Gene ID: (Human) 57695, (Mouse) 319651, (Rat) 100361658
G1/S transition of mitotic cell cycle
ubiquitin-dependent protein catabolic process
mitotic nuclear division
protein deubiquitination
protein K11-linked deubiquitination
cell division
protein K48-linked deubiquitination
proteolysis
cell cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
