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Invitrogen
Ubinuclein 2 Polyclonal Antibody
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产品信息
PA5-54071
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human Ubinuclein 1/2. Recombinant protein control fragment (Product #RP-92771).
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SVTNQNVTPF GMLGGLVPVT MPFQFPLEIF GFGTDTAGVT TTSGSTSAAF HHSLTQNLLK GLQPGGAQHA ATLSHSPLPA HLQQAFHDGG QSKGDTKLPR KS
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.
靶标信息
Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ubinuclein 1; Ubinuclein-2; UBN1; VT; VT4
基因别名: KIAA2030; UBN2
UniProt ID: (Human) Q6ZU65
Entrez Gene ID: (Human) 254048
