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Invitrogen
VCP Polyclonal Antibody
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VCP Antibody (PA5-119499) in IHC (P)
Immunohistochemistry (Paraffin) analysis of VCP in porcine pancreas tissue using VCP Polyclonal Antibody (Product # PA5-119499) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
产品信息
PA5-119499
产品规格
种属反应
Human,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Valosin Containing Protein. The antigen corresponds to amino acid range 125-371 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 15S Mg(2+)-ATPase p97 subunit; epididymis luminal protein 220; epididymis secretory protein Li 70; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog
基因别名: ALS14; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p93; p97; TERA; VCP
UniProt ID: (Pig) P03974, (Human) P55072, (Rat) P46462
Entrez Gene ID: (Pig) 397524, (Human) 7415, (Rat) 116643
ATP binding
lipid binding
ATPase activity
protein binding
protein phosphatase binding
protein domain specific binding
polyubiquitin binding
ubiquitin protein ligase binding
deubiquitinase activator activity
K48-linked polyubiquitin binding
MHC class I protein binding
identical protein binding
ADP binding
ubiquitin-like protein ligase binding
poly(A) RNA binding
BAT3 complex binding
ubiquitin-specific protease binding
receptor binding
protein complex binding
double-strand break repair
ubiquitin-dependent protein catabolic process
ER to Golgi vesicle-mediated transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to DNA damage stimulus
protein ubiquitination
protein N-linked glycosylation via asparagine
translesion synthesis
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
positive regulation of protein complex assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein hexamerization
positive regulation of protein catabolic process
protein homooligomerization
aggresome assembly
positive regulation of protein K63-linked deubiquitination
positive regulation of Lys63-specific deubiquitinase activity
autophagy
proteasomal protein catabolic process
macroautophagy
endosome to lysosome transport via multivesicular body sorting pathway
cellular response to heat
stress granule disassembly
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
endoplasmic reticulum stress-induced pre-emptive quality control
autophagosome maturation
cellular response to arsenite ion
DNA repair
NADH metabolic process
positive regulation of mitochondrial membrane potential
viral genome replication
endoplasmic reticulum unfolded protein response
regulation of apoptotic process
establishment of protein localization
ATP metabolic process
error-free translesion synthesis
ER-associated misfolded protein catabolic process
flavin adenine dinucleotide catabolic process
regulation of aerobic respiration
positive regulation of oxidative phosphorylation
positive regulation of ubiquitin-specific protease activity
positive regulation of ATP biosynthetic process
