Invitrogen

VCP Monoclonal Antibody (5)

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48个已发表图片
58 篇参考文献
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VCP Monoclonal Antibody (5)

产品信息

MA3-004

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看26篇已发表文章 26篇已发表文章

免疫组化 (IHC)

-
查看11篇已发表文章 11篇已发表文章

免疫组化（石蜡） (IHC (P))

1:500
查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

1:500
-

免疫细胞化学 (ICC/IF)

1:20-1:200
查看10篇已发表文章 10篇已发表文章

流式细胞分析 (Flow)

1/400
-

免疫沉淀 (IP)

Assay-dependent
查看5篇已发表文章 5篇已发表文章

亲和纯化 (AP)

-
查看5篇已发表文章 5篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Human, Mouse, Yeast

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

5

抗原

Synthetic peptide corresponding to residues C G(792) G S V Y T E D N D D D L Y G(806) of mouse VCP.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2214638

产品详细信息

MA3-004 detects VCP protein in human, mouse, and rat samples.

MA3-004 has successfully been used in Western blot immunoprecipitation, and immunohistochemical procedures. By Western blot, this antibody detects an ~97 kDa protein representing VCP from total lysate of cultured human B cells.

The MA3-004 immunogen is a synthetic peptide corresponding to residues C G(792) G S V Y T E D N D D D L Y G(806) of mouse VCP. This peptide (Cat. # PEP-239) is available for use in neutralization and control experiments.

靶标信息

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; epididymis luminal protein 220; epididymis secretory protein Li 70; homolog of yeast cdc48; Inv protein; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog

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基因别名: 3110001E05; ALS14; CDC48; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; p97/VCP; TERA; VCP

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UniProt ID: (Human) P55072, (Mouse) Q01853, (Rat) P46462

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Entrez Gene ID: (Human) 7415, (Mouse) 269523, (Rat) 116643

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功能
protein binding ATP binding lipid binding ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding poly(A) RNA binding BAT3 complex binding ubiquitin-specific protease binding nucleotide binding receptor binding hydrolase activity protein complex binding
参与通路
DNA repair double-strand break repair ubiquitin-dependent protein catabolic process transport ER to Golgi vesicle-mediated transport activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization positive regulation of protein catabolic process protein homooligomerization aggresome assembly ER-associated misfolded protein catabolic process positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity NADH metabolic process autophagy positive regulation of mitochondrial membrane potential endoplasmic reticulum unfolded protein response ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization ATP metabolic process error-free translesion synthesis flavin adenine dinucleotide catabolic process autophagosome maturation regulation of aerobic respiration positive regulation of oxidative phosphorylation positive regulation of ubiquitin-specific protease activity positive regulation of ATP biosynthetic process
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